Randomized, controlled intervention trial of male circumcision for reduction of HIV infection risk: the ANRS 1265 Trial.
BACKGROUND: Observational studies suggest that male circumcision may provide protection against HIV-1 infection.A randomized, controlled intervention trial was conducted in a general population of South Africa to test this hypothesis.METHODS AND FINDINGS: A total of 3,274 uncircumcised men, aged 18-24 y, were randomized to a control or an intervent